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Dual modifications, such as 2,4- and 2,5-sugar modifications, have been employed in the development of siRNA therapeutics to further expand the potential of ribose modifications

doi:10.1016/j.nutres.2016.03.010 Dzupina A, Pella D, Zenuch P, et al

A less efficient reaction is possible for longer acyl groups with fatty acid chains of up to ten carbon atoms in length [144]

The deficiency can range from mild to severe

Vagus nerve stimulation as a potential therapy in early Alzheimers disease: a review
