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These findings indicate advanced uremia , a state of retained nitrogenous waste products that can lead to life-threatening complications requiring urgent renal replacement therapy, such as the development of a pericardial friction rub , which indicates pericarditis

Coffee and highly caffeinated beverages can interfere with the absorption of delicate amino acids and antioxidants in the gut

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doi: 10.1016/j.mad.2006.02.007 20 Del RioD.Rodriguez-MateosA.SpencerJ