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In fact, the majority of selenoproteins have only one Sec residue and, in some cases, it participates in the analog motif of thiol oxidoreductase C-X-X-C, i.e., C-X-X-U or U-X-X-C (Table 4)

Indeed, there is evidence that co-targeting IGF-1R and Src family kinases by combining anti-IGF-1R mAbs/IGF-1R TKIs with dasatinib resulted in more effective growth inhibition than single-agent treatments in rhabdomyosarcoma cell lines [150]

Minimal reported adverse effects but lacks Phase 3 validation

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