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Generally, t 1/2 values of peptide drugs range from a few minutes to an hour ( The radioisotope probe assay is a cost-effective and fast method for generating informative data for early preclinical/pharmacokinetic absorption, digestion, metabolism, and excretion studies of biotherapeutics ( Determination of metabolites was the most challenging aspect of this study

p53 acts as a sensor for cellular stresses such as genotoxic stress, hypoxia, telomere loss or oncogenic signalling So what happens when FOXO4 and p53 interact

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The objective of this study was to evaluate the therapeutic activity of transient FAP-targeted CAR-T (FAPCAR-T) cells generated in vivo via a novelly designed LNP-mRNA system and the lung regeneration mechanism in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis

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