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Description
They have a dual role in biological systems, both beneficial than harmful depending on their nature and concentration as well as location and length of exposure (1)

** (2012) Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13

10.1038/mp.2011.175 13 FryeR

The situation becomes more serious with nicotinamide doses of 250 mg per day that have caused reversible hepatotoxicity in both animals and humans [6]

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
