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Phosphodiesterase inhibitors Cilostazol has been evaluated for its preventive effect on PIPN, and when comparing the cilostazol group (40%) to the control group (86.7%), there was a significant difference in the occurrence of grade 2 and 3 peripheral neuropathies

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We also found that autophagy genes were required for proteostasis in other tissue-specific aggregation models caused by protein misfolding, as inhibition of autophagy genes enhanced paralysis and movement defects in animals harbouring temperature-sensitive missense mutations in genes affecting the function of paramyosin and myosin (muscle) (Supplementary Fig

Because of the latter finding and the lack of nest formation, the term genital lentiginosis has been advocated by some [16]