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NO generated in endothelial cells diffuses rapidly to adjacent smooth muscle cells, which activates soluble guanylate cyclase (sGC) and allows the conversion of GTP to cyclic GMP, initiating a signaling cascade leading to vasodilation [8, 9]
Then, these AP sites are cleaved by an AP endonuclease
Additionally, vaping may also disrupt the regulation of blood flow in the lungs, specifically the hypoxic pulmonary vasoconstriction response
10.3389/fimmu.2020.00353 218 SongJ.ZhangY.FrielerR
