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Overexpression of FSP1 or treatment with Fer-1, a ferroptosis inhibitor, significantly reversed the apoptosis, ferroptosis, and lipid peroxidation induced by the activation of the MPO/HOCl signaling pathway, exerting neuroprotective effects

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Abstract High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action