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doi: 10.2147/DMSO.S281186 39 ZhaoXHuHWangCBaiLWangYWangWet al

Dis ., 25 (4), 370375

Recent evidence suggests that aberrant brain-gut pathways, mitochondrial enzymopathies, gastrointestinal motility disorders, calcium channel abnormalities, and hyperactivity of the hypothalamic-pituitary-adrenal axis in response to a triggering environmental stimulus are involved in the CVS development ( This review was developed by a joint task force of the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP) to propose future research directions