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52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

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Functional studies reveal that around 36 months of age the cardiomyocyte-specific GR knockout mice exhibit significantly compromised heart function characterized by left ventricular systolic dysfunction

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For example, peak levels of ovarian hormones during proestrus is correlated with increased levels of proliferation in the SGZ [138, 139]