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This synergy likely stems from attacking the healing process through multiple distinct pathways simultaneously

Front Cell

(iv) Detoxification purposes : The body natural detox mechanisms can be impaired by pollutants and unhealthy lifestyles

[DOI] [PMC free article] [PubMed] [Google Scholar] 458

The former predominantly releases interferon- (IFN-) and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are less relevant to CRS pathogenesis, compared to interleukins (IL-6, IL-8, IL-10, IL-1a), tumor necrosis factor- (TNF-) and monocyte chemoattractant protein-1 (MCP-1), among others, which are released by CAR-T cells
