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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

Roberts P, Der C

Controlled long-term data comparing tolerance development between the two compounds does not yet exist

As described previously, CD38 inhibits the proliferation of memory CD4 + and CD8 + T cells via the alternative ectoenzymatic pathways that produce ADOresponsible for its suppression [51]