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In neuroinflammation, activated microglia sustain the release of pro-inflammatory cytokines, perpetuating chronic inflammation and generating cytotoxic molecules such as ROS and RNS (49)

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TRT has direct metabolic effects, including: Muscle growth : Testosterone directly stimulates muscle protein synthesis, growth, and repair, especially of the fast-twitch muscle fibers that power strength and hypertrophy, says Lee

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Sherwin E., Sandhu K.V., Dinan T.G., Cryan J.F