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Given the strong decrease in the steady state levels of mitochondrial GSH upon SLC25A39 loss, we reasoned that SLC25A39 may mediate GSH import into mitochondria

By contrast, a porcine enzyme entitled SscGST A2-2, linked to ovarian follicular differentiation and showing 84% sequence identity with the human enzyme, was found to approach the high ketosteroid activity of HsaGST A3-3 (Ismail et al., 2021)

doi: 10.1038/s41467-024-47549-1

Mounting pressure in the microenvironment: fluids, solids, and cells in pancreatic ductal adenocarcinoma

Further inhibition of Nrf2 does not significantly alter Sirt1 expression, indicating that Nrf2 is a downstream target of Sirt1