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Despite their selectivity, aptamers may suffer from limited nuclease stability and require chemical modification (e.g., 2-fluoro or 2-O-methyl substitutions) to remain intact in biological fluids [160]

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38, Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH

Importantly, these levels were still lower than those reported in the non-inducible liver-specific Gclc KO mouse strain 30

Thus, there is an urgent need to standardize topical administration trial reports and datasets