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Interestingly, one of the studies demonstrated an inverse relationship between diurnal salivary cortisol levels and hippocampal glutamate concentration in bipolar patients (262)
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Furthermore, the human brain is extremely susceptible to oxidative stress due to its high consumption of the total basal oxygen budget (about 20%) to support ATP-intensive neuronal activity, its shortage of antioxidants compared to other organs, as well as its lack of cellular regenerative capacity [58]
