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Although the number of lacunes correlates strongly with cognition, the low frequency of incident lacunes means lacune count requires much larger sample sizes than the other MRI markers (676)

Much of the mechanistic insight stems from animal models or in vitro systems, which may not accurately replicate the physiological complexity of human perimenopause

SJMS is grateful for funding obtained from BioComp 3.0 Dynamic Membrane Processes in Biological Systems

Freitas, P

The PNMT gene is located on chromosome 17q12 and is composed of 4 exons that generate two alternatively spliced mRNAs, one of which is non-coding, the other encodes the functional protein of 282 amino acids