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however, the genetics of most biomarker traits are shared between males and females [52]

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Lastly, it is also known that stress can influence clock function at the level of the SCN and also at the level of the adrenal circadian oscillator leading to phase shifts (164)

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Further complicating diagnosis, localized disease is largely asymptomatic or accompanied by ill-defined symptoms, there is a paucity of diagnostic biomarkers for earlier stage tumors, and the difficult to access anatomical location of the pancreas prevents routine office-based screening
