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It is under investigation in preclinical and clinical studies on overweight, obesity, and metabolic disorders, where researchers have examined its effects on body weight and energy intake, including when combined with GLP 1 receptor agonists such as semaglutide, but it is not an approved therapy

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To further validate the presence of vasculature within the organoids, we generated volume-rendered 3D reconstructions in cross-section, where we observed clear lumen with a median diameter of 8.3 m (interquartile range of 6.910.7 M), which is in the range of capillary lumens (510 m) (Fig