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Suppliers sell the reference standard as an iodide salt, and the literature describes it as a selective NNMT inhibitor with an IC50 near 1.2 micromolar, meaning it shuts the enzyme down at low concentrations without hitting related enzymes

Major bleeding occurred in a higher percentage of patients assigned to therapeutic-dose anticoagulation compared to those assigned to usual-care pharmacologic thromboprophylaxis [62]

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They are highly expressed in the cytoplasmic and mitochondrial compartments of cardiomyocytes and represent an important defense mechanism within the heart [4, 7]