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Exploring the mechanism of berberine intervention in ulcerative colitis from the perspective of inflammation and immunity based on systemic pharmacology

Indeed, divertin non-enzymatically suppressed cytokine-induced MLCK1 recruitment to PAMR, which promotes leak pathway-dependent barrier loss

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Furthermore, dapagliflozin and insulin significantly decreased serum Cr levels in mice with DKD, whereas there were no changes in blood urea nitrogen (BUN) levels (Figure 1G, H)
