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Vitamin B12 also plays a key role in DNA synthesis, supports cell growth and repair, and contributes to energy metabolism

While significant adverse events are uncommon at research-appropriate doses, it's prudent to monitor for any unexpected physiological changes

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Patients who have undergone gastric sleeve surgery should maintain regular long-term follow-up with their bariatric team, as recommended by NICE and BOMSS guidelines

Minimal response may warrant increasing by 50-100mcg