glutathione s-transferases resistance The Multifaceted Role of in Health and Disease Glutathione transferases: substrates, inihibitors and

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Table 3-12, prepared from the data of Vamvakas et al

This functional disorder not only disrupts the normal regulatory mechanisms of blood vessels but also leads to increased blood pressure, arterial stiffness, and remodeling of small arteries, ultimately resulting in multi-organ damage (Boutouyrie et al., 2021

Mild nausea (6% incidence) was the only reported adverse effect, with no treatment discontinuations (El-Nahas et al., 2020)

Subsequently, clinical studies with pembrolizumab, another anti-PD-1 monoclonal antibody, in mCRPC patients also proved ineffective, indicating that monotherapy with PD-1 inhibitors in this patient population did not yield significant objective responses (Scheid et al., 2016)