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Studies have shown that downregulation of CHRNB2 may suppress the -catenin pathway by regulating its upstream factors, such as TCF7L2, SOX17, SRY, and SOX6, thereby affecting the invasion and migration capabilities of cancer cells [143]
Additionally, macrophages and natural killer cells present in the lamina propria of the intestinal mucosa serve as vital constituents of the intestinal immune barrier and actively participate in immune responses related to enteric functions (Li et al

Thus, enhancing excitatory neurotransmission and plasticity in physiology but promoting excitotoxicity in disease context

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