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10,11 Therefore, it is imperative that pharmacists recognize signs and symptoms of overdose and toxicity, and counsel their patients on proper dosing and usage

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To date, some compounds, including nutlins 13 , spirooxindoles 14 and benzodiazepinediones 15 , have been reported to disrupt MDM2 binding to the TAD of p53, but few studies target other p53-negative regulators, such as MDMX