glutathione and small cell lung cancer Disruption of NADPH homeostasis by total flavonoids from Adinandra nitida Merr. ex Li leaves triggers ROS-dependent p53 activation leading to apoptosis in non-small cells NRF2 supports non-small cell lung
Description
Nature 452:4550 Kangaspeska S, Stride B, Mtivier R, Polycarpou-Schwarz M, Ibberson D, Carmouche RP, Benes V, Gannon F, Reid G (2008) Transient cyclical methylation of promoter DNA
GSH is also regenerated from GSSG by glutathione reductase (GR) in a NADPH-dependent reaction maintaining the intracellular GSH pool under sustained oxidative challenge
Karger, Basel, in press
Key protocol elements include proper dosage calculation (typically 5-10mg per cycle), consistent daily administration timing, appropriate cycle length (10-20 days), and adequate rest periods between cycles
They change their minds
