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doi: 10.1016/j.lfs.2005.05.103 46

Piperine was also included in the not prohibited group, based on a description by AIS found in the characterization of curcumin from group B, which states, curcumin is an unstable compound and its bioavailability is very poor in its unmodified form

In this work, rats with intrastriatal 6-OHDA lesions were given ALC at dosages of 100 or 200 mg/kg/day for one week

In detail, it up-regulated level of acetylated H3K27 induced by LAC that binds to the glutamate receptor metabotropic 2 (GRM2) promoter and acetylation of the NF-B p65 subunit, which enhanced the transcription of the GRM2 gene encoding mGlu2 receptor in the hippocampus and prefrontal cortex (86)

2019;9 doi: 10.1038/s41598-019-47216-2
