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This relentless cycle of oxidative stress and mitochondrial dysfunction is a primary driver of the debilitating fatigue and post-exertional malaise (PEM) that define Long COVID and ME/CFS

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At the time of appointment, a majority of the guideline panel, including the chair and the vicechair, had no conflicts of interest as defined and judged by ANMS policies

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A prolonged circulation time and increased ventilatory responsiveness to rising PCo2 combine to produce ventilatory control system instability (high loop gain), which is nearly solely responsible for this breathing pattern (White, 2005)