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We identify a missense variant in GLP1R that is associated significantly with increased efficacy of GLP1 medications ( P = 2.9 10 10 ), with an additional 0.76 kg of weight loss expected per copy of the effect allele

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10.1371/journal.pone.0162590 41 LueticK.SucicM.VlainicJ.HalleZ

The peptide's interaction with dopaminergic and serotonergic neurotransmitter systems extends its mechanism into the nervous system, connecting each biological action directly to a documented benefit across multiple tissue types