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In addition, R848-loaded mannosan decarboxylated polylactic acid nanoparticles (Man-pD-PLGA-NP@R848) can target TAMs in a mannose receptor-mediated manner and further reprogram TAMs to an anti-tumor phenotype thereby inhibiting tumor progression by reprogramming immunosuppressive TME from cold tumors to hot tumors (42)

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2020;122 doi: 10.1016/j.biopha.2019.109695

186 On the other hand, plasma cysteine levels have been reported to show an inverse correlation with the risk of cervical dysplasia, showing a weak negative association between the levels of cysteine and the development of low-grade, but not high-grade, squamous intraepithelial lesions in a large casecontrol study

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