acetyl l carnitine deficiency in patients with major depressive disorder Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health Role of carnitine in disease

doi:10.1016/j.cpcardiol.2025.103169 Fallahtafti P, Farooqi M, Looha MA, et al

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Nevertheless, the clinical translation of ferroptosis-based therapies faces several challenges, including the lack of specific biomarkers hindering precise patient stratification, tumor heterogeneity causing variable therapeutic responses, off-target toxicity in normal tissues limiting the therapeutic window, and the crosstalk between ferroptosis and other regulated cell death pathways as well as the complex regulatory effects of the tumor microenvironment complicating mechanistic studies and intervention strategies

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