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Elevated Ca 2 concentrations within the mitochondria can trigger an increase in H 2 O 2 production, ultimately leading to mitochondrial dysfunction, excessive ROS generation, and initiation of apoptosis [448,454]

Through disruption of hydrophobic lipid-lipid and lipid-protein interactions, this change may result in structural changes to biomembranes and lipoproteins

In a transamination reaction, glutamate can donate its amino group for new amino acid synthesis and deaminated to 2-oxoglutarate [3]

As one of the main components, crocin improved depressive symptoms and reduced the expression of inflammatory cytokines (e.g., IL-1, IL-18, and TNF-) in the hippocampus of LPS-depressed mice (96)

The Japanese experience with basic fibroblast growth factor in cutaneous wound management and scar prevention: a systematic review of clinical and biological aspects