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Special Populations Older adults often face declining B12 absorption due to reduced stomach acid

There are specific scenarios where combining these two forms of B12 might be considered, as part of a tailored treatment plan: Reducing Injection Frequency: For some individuals who require lifelong B12 due to malabsorption but dislike frequent injections, a doctor might explore if high-dose oral supplements can help maintain adequate levels between less frequent injections

Staley K, Ahmadi KR, Carter K, et al

It has been shown to be cyclic due to a disulfide bridge between two cysteine residues

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