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Mechanistically, mitochondrial TCA cycle and ETC could promote cysteine deprivation-induced ferroptosis by inducing mitochondrial membrane potential hyperpolarization and lipid peroxide accumulation

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References Hou, Y

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ROLE OF GLUTATHIONE METABOLISM AND GLUTATHIONE-RELATED ANTIOXIDANT DEFENSE SYSTEMS IN HYPERTENSION via the formation of nitrosothiols and nitrosohemoglobin