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Collectively, the development of enzalutamide, abiraterone acetate, and other new agents validate the importance of the AR as an important therapeutic target

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Moreover, in the NH 4 Cl-treated human astrocytes, increased concentration of 3-methyl-2-oxovaleric acid, which was ammonia induced and played a crucial role in neurological impairment, was significantly decreased with l-carnitine co-treatment

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