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Researchers have identified other mitochondrial-derived peptides, such as Humanin and SHLPs, or small humanin-like peptides, but MOTS-C exhibits unique effects on energy sensing and gene regulation in response to metabolic stress

In rats fed a high-fat diet, an increase in visceral fat accumulation and insulinemia were associated with enhanced catalase activity in liver [47], while amelioration of these features by pioglitazone decreased catalase activity [47]

ET is a rare antioxidantcytoprotectant capable of crossing the bloodbrain barrier, a feature that is necessary to treat neurodegenerative disorders where oxidative stress plays a central role in disease progression (111)

Moreover, individual differences (e.g., genetic background, metabolic rate, etc.) may influence the absorption and metabolism of antioxidants, leading to different patients responding differently to the same dose

172 (5), ITC33ITC48