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First, copper ionophores are small molecules that bind and shuttle copper into the cells, which are valuable tools to elucidate the mechanisms of copper toxicity [56]

Therefore, in most cases damaging effect of hydroxyl radical is restricted to the site of its formation

M., Bussadori, S

We discuss how gut microbiota modulate therapeutic and side effects of statin, and examine the mechanisms by which the microbiome exerts its effects on statin response and cardiovascular diseases

Moreover, histone H3K9 acetylation has been demonstrate to induce ABCG2 gene transcription in multidrug resistant cells (To et al., 2008), further supporting that the nuclear translocation of PDC may confer MDR in cancer cells