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The virus is one of the most common causes of nonbacterial gastroenteritis epidemic worldwide

This mismatch is a consequence of the sn -2 chain bending perpendicular to the membranes plane [406,407]

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A variant here, P478L, is associated with SPCD 55 , and in human OCT1, the equivalent residues are also implicated in the inward-outward conformational transition 29

Sequence degeneracy involves mismatches ranging from 1 to 3 base pairs per 15-mer ARE, a higher GC content in the 3 bp spacer between hexamers in imperfect AREs, and over two-thirds of AREs are recognized to consist of half sites only, with a minority making up canonical 15mer AREs [53, 56]