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Description
In the mammals, forkhead transcription factors of the O class, i.e., FOXO1, FOXO3, FOXO4, and FOXO6 proteins, play a paramount role in the usual functional complexity of the cell, its proliferation, differentiation, and death as well as in the progression of several diseases
10.3969/j.issn.1672-5174.2009.04.020 246 ShenH.LiuX.JiangM.LuoG.WuZ.ChenB.et al (2019)

doi: 10.1146/annurev-pathol-121808-102144

Beyond AD, astrocyte-mediated ROS homeostasis disruption has been implicated in the neurodevelopmental disorder Fragile X syndrome

Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity
