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The novel IVF treatment involves transferring the mothers nDNA from an affected egg into an enucleated egg from an unaffected donor, resulting in an embryo containing nDNA from both parents but mostly wild-type mtDNA from the healthy donor and a much lower risk of mitochondrial disease

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Oncometabolite d-2-hydroxyglutarate impairs -ketoglutarate dehydrogenase and contractile function in rodent heart

Stimulation of carnitine palmitoyltransferase 1 improves renal function and attenuates tissue damage after ischemia/reperfusion

Zu einem der typischen Symptome eines entsprechenden Mangels gehren infolgedessen Verfettung und bergewicht