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Deisseroth AB, Kavanagh JJ, Hanania EG, Fu S, Kornblau SM , Estey EH, Talpaz M, Kantarjian HM, Claxton DF, Reading CL, Dixon DA, Anderson RW, Lopez-Berstein G, Holmes FA, Logothetis CJ, Andreeff M, Benedict WF

Shifting by four or five days disrupts the steady state and may increase breakthrough symptoms between doses

Together, in laboratory models, they support research into synergistic GH release mechanisms, pulsatile secretion patterns, and downstream IGF-1 signaling

Other advantages included rapid response, high selectivity, and low cytotoxicity

Vero cells were detached from the flasks by treatment with trypsin (0.5 mg/ml)/EDTA (0.2 mg/ml) in PBS for 5 min at 37 C