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Evidence derived from human observational studies, autopsy findings, and experimental models suggests that sustained androgen receptor overstimulation may induce structural, functional, and metabolic alterations that compromise cardiovascular homeostasis (68, 69)

Antioxidant Protection Aging is often a result of oxidative stress caused by environmental toxins and UV exposure

Signaling pathway involving release and caspase 3 activation is conserved

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Phosphorylation of AMPK facilitates the activation of Nrf2 and reduces free radical levels by upregulating the expression of HO-1, a downstream target of Nrf2