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The type of cells used in these packs see their resistance drop drastically once hot and in use

This triggers an increase in melanin, the pigment that gives skin its color and provides protection against UV radiation

in this patient one area of pigmentation comes close to the limbus

These changes are often temporary but can last for some people

Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition