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Both the residues Arg423 and Arg520 have been suggested to play a role in acceptor binding and imparting broader stereospecificity to CapD in accepting both L- and D-forms of amino acids as acceptors
If you have an MTHFR mutation you are a candidate for B12 shots

Proteome Sci 6:8

Despite the high level of reduced GSH, a small change in the ratio between the reduced and the oxidized GSH form (GSH:GSSG) can substantially affect E GSH , thus impairing cellular redox balance 17