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Injections of EVs from NSCs and MSCs enhance learning and memory functions in AD mice (Xia et al., 2022)

Mechanistically, Epitalon's small size allows it to enter cells and potentially reach the nucleus, where researchers hypothesize it interacts with chromatin-associated proteins to influence gene transcription consistent with Khavinson's broader "peptide bioregulator" theory, which proposes that short tissue-derived peptides act as gene-expression regulators specific to their tissue of origin

The analysis of fissure numbers per microscopy field across different experimental groups reveals significant variations in brain tissue morphology (Figure 8B, F (5, 30) = 48.51, p 0.05)