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The DEA schedules substances based on accepted medical use, documented abuse potential, and the risk of physical or psychological dependence developing in users

Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

The authors thank the following persons for their contributions to this work: Dolores Otero-Criado, Carlos Carvajales Fernndez, Rosa Zurdo-Baz and Raisa Gonzlez-Prez

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