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Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, et al

While IGF-1 LR3 was engineered for extended half-life and systemic activity, IGF-1 DES follows the opposite strategy: very short half-life (20-30 minutes) but extreme potency at the site of injection

Because subcutaneous adipose tissue has a lower density of growth hormone receptors, it may not be as readily mobilized by growth hormone-induced lipolysis

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Endocrine disrupting chemicals: Interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors