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There are also certain drugs and health conditions that can increase the likelihood of developing a B12 deficiency such as: alcohol abuse, antacid use, smoking, celiac disease, other digestive concerns, pregnancy, a strict vegetarian or vegan diet, and even natural aging

This minimizes local injection reactions and allows independent dose titration

Notably, enzymes such as aldehyde dehydrogenases (ALDHs) and glutathione S-transferases (GSTs) maintained relatively high expression at Day 45, possibly supporting metabolic adaptation to a diverse cellular environment

Unknown long-term profile: No human safety data, so caution and monitoring are advised

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