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Although clinical studies specifically addressing AX effects on the brain in obesity are still lacking, preclinical data indicate that AX is able to cross the bloodbrain barrier and accumulate in metabolically relevant brain regions, including the hippocampus [87]

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Kolditz C-I, Langin D (2010) Adipose tissue lipolysis

An unblinded RCT of 60 patients suggested that verapamil administered with iontophoresis had better results than verapamil administered intralesionally