glutathione conjugation as a bioactivation reaction Glutathione-Mediated of Anticancer Drugs: An Overview of Mechanisms and Biological Significance for Drug Detoxification and Metabolism of Glutathione S-Conjugates: Multiple

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In the present work, we have designed a context-based dynamic metabolic model to establish that the coordinated functioning of glutathione peroxidase (GTHP), glutathione oxidoreductase (GTHO) and NADPH oxidase (NOX) is crucial in determining cancerous transformation, specifically in gliomas